TAp63alpha Induced Apoptosis Inhibited by Kaposi's Sarcoma Herpesvirus Latency Nuclear Antigen
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منابع مشابه
TAp63alpha Induced Apoptosis Inhibited by Kaposi’s Sarcoma Herpesvirus Latency Nuclear Antigen
Kaposi’s sarcoma-associated herpesvirus (KSHV) infects a variety of human cells including cells of epithelial, mesenchymal and endothelial origin. The latency associated nuclear antigen (LANA) of this virus regulates the transcription of a number of viral and cellular genes essential for the survival of the virus in the host cell. TAp63α can induce apoptosis in stressed cells by upregulating va...
متن کاملThe latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.
Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymphoma, KS and multicentric Castleman's disease. Latently infected cells have multiple extrachromosomal copies of covalently closed circular KSHV genomes (...
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Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphomas (PELs). Previously, we demonstrated that KSHV blocks IL-4-induced STAT6 phosp...
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The latency-associated nuclear antigen (LANA) is central to the maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) and to the survival of KSHV-carrying tumor cells. In an effort to identify interaction partners of LANA, we purified authentic high-molecular-weight complexes of LANA by conventional chromatography followed by immunoprecipitation from the BC-3 cell line. This is the firs...
متن کاملLatency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1.
Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus plays an important role in maintenance of the viral genome during latent infection. LANA additionally participates in the transcriptional regulation of several viral and cellular promoters. When tethered to constitutively active promoters, the protein exhibits transcriptional repressor activity. In this report,...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2015
ISSN: 2157-2518
DOI: 10.4172/2157-2518.1000221